When it comes to what to know about menopause and collagen, let’s start with the basics. This transitional stage is when collagen begins to degrade at a faster rate, affecting both the skin and joints.
Essentially, as we age, the layers of the skin, from the epidermis (the most superficial) to the joints, become reduced and disorganised. This results in a loss of skin elasticity, increased dryness, and the appearance of fine lines. At the joint level, women in perimenopause and menopause may note greater stiffness, pain and a decrease in cartilage cushioning.
The science of menopause: Why collagen declines after 40
It all starts with something called oxidative stress, which happens when there’s a glitch in the balance between harmful molecules (free radicals) and the body’s natural ability to mop them up.
As this damage builds up, the cells that produce the collagen for our skin and joints start to slack off. They just can’t repair our connective tissues as quickly or as well as they used to. This constant wear and tear also causes low-grade inflammation, called “inflammaging.”
There’s another big thing happening, too: our cellular energy metabolism also shifts with age. Inside our cells, we have tiny power packs called mitochondria. As we age, these “batteries” begin to slow down, meaning our bodies have less energy to build new collagen.
“A big part of how you age depends on how you live. While your genes do play a role, they actually only account for about 7% of the puzzle”
For women, a lot of this is down to changing hormone levels – specifically oestrogen and progesterone, which are directly linked to collagen production.
But here’s the good news: a huge part of how you age depends on how you live. While your genes do play a role, they actually only account for about 7% of the puzzle. The rest comes down to your lifestyle, your environment, and even the “good bacteria” living in your gut.
Dietary secrets: The best foods to naturally boost collagen levels
Ensuring you consume sufficient protein as part of a balanced menopause-friendly diet, alongside staying properly hydrated, can make a world of difference to collagen health. A poor diet – whether lacking in protein or hydration – stifles the body’s ability to synthesise and regenerate collagen.
Furthermore, a high intake of sugar and ultra-processed foods accelerates the deterioration by triggering glycation, a process that hardens and weakens collagen fibres.
© Getty ImagesIt isn’t just down to your diet. Things like too much sun, smoking, and alcohol all get in the way of your circulation. This makes it much harder for your body to hold onto collagen, meaning your skin and joints age a lot quicker.
Similarly, chronic stress and a lack of sleep disrupt hormone production and drive up inflammation – and both of those impacts take a toll on tissue regeneration.
Cellular regeneration: Essential nutrients for skin and joint health
Vitamin C and hydrolysed collagen peptides are essential for collagen synthesis; however, the body may prioritise their absorption in other tissues before they ever reach the skin and joints.
“It is important to manage expectations: collagen supplements are not a ‘magic bullet'”
To optimise production, certain cofactors are required.
- Compounds such as glutathione, alpha-ketoglutarate (AKG), NAD+, and nicotinamide riboside (NR) boost cellular regeneration and mitochondrial function—both of which are vital for the activity of fibroblasts and chondrocytes.
- Omega-3, turmeric, and trans-resveratrol help dampen the inflammation that accelerates collagen breakdown.
- Silicon and manganese strengthen the extracellular matrix, promoting firmness and elasticity within the connective tissue.
- Zinc and copper are also indispensable for the synthesis and stability of new collagen.
- The foundation of the dermis contains key compounds such as hyaluronic acid, chondroitin sulphate, glucosamine sulphate, and glycoproteins, all of which are essential for hydration and elasticity. Incorporating bone broth – made from joints, marrow, and cartilage – is a natural way to provide these nutrients and support the regeneration of connective tissue.
- Vitamin E and antioxidant-rich foods, such as blueberries and goji berries, help to shield collagen structures and slow down their degradation.
Androgens and thyroid function also play a significant role. Shifts in androgen receptors can impact both the skin and hair; therefore, balancing these hormonal factors alongside proper nutrition is vital to protect the skin and cartilage from degeneration.
© Getty ImagesDo collagen supplements actually work? The truth behind the hype
For the body to actually utilise the collagen we consume, it must first be broken down into amino acids and bioactive peptides. Hydrolysed collagen is the most bioavailable form; it has undergone an enzymatic process that pre-digests the protein molecules into much smaller fragments.
However, it does more than just supply the essential building blocks such as hydroxyproline, glycine, and proline. These bioactive peptides also function as cellular messengers. They effectively “signal” our fibroblasts and chondrocytes – the specific cells responsible for synthesising collagen in our skin and joints – to get to work.
“While Types I and III collagen are indispensable for skin firmness, hydration, and elasticity, Type II is the specialist for joint health”
Many people are familiar with marine and bovine collagen, which are widely recommended for how easily they are absorbed.
Generally, the effects become visible within eight to 12 weeks, though some people notice a difference in their skin after just four weeks, or find relief from joint discomfort in as little as three weeks.
The collagen warnings to know
That said, it is important to manage expectations:
- Collagen supplements are not a “magic bullet” – they won’t vanish deep-set wrinkles or reverse years of severe sun damage.
- Pairing your supplement with Vitamin C is essential for optimising collagen synthesis.
- It is also vital to choose collagen from a certified source – particularly when it comes to marine collagen to ensure it is free from contaminants such as heavy metals.
Lastly, while many suggest taking collagen on an empty stomach, there is currently no firm evidence that absorption significantly changes at other times of the day.
About the expert:
Andrea Carucci is an integrative health and menopause specialist with over 30 years of clinical experience. She is the author of the Spanish-language book SOS: Menopausia a la vista (SOS: Menopause is on the Horizon) and a lecturer on the Master’s in Integrative Fertility at the European University of Vitoria (EUNEIZ).
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