Rosie O’Donnell shows her body transformation after using weight-loss medication: ‘This is me now’

Rosie O’Donnell is embracing a new chapter in both her personal and professional life, and her recent body transformation has played a part in her journey. The comedian, now 63, recently made headlines after moving to Ireland and documenting her new life with her family, including their struggles and routines.

But this time, the actress decided to show another part of her life, showing her weight-loss journey. She took to social media to post a photo of her dramatic transformation, after using Mounjaro.”

“I can’t believe this is me now,” she wrote, adding the hashtags, ‘Mounjaro’ and ‘Body Dismorphia,’ referring to her disbelief after seeing the recent photo taken of her, in comparison to how she felt before starting using the weight-loss medication. 

Her weight loss comes after using Mounjaro, an anti-diabetic medication that has gained popularity for its side effect of promoting weight loss. The medication, which is used for Type 2 diabetes, has been part of her health journey, apart of her lifestyle changes since moving to Ireland in early 2025.

© Rosie O’Donnell/Instagram

In a March 2025 TikTok video, she shared how her lifestyle has evolved since relocating with her youngest child, Clay, 12. “It’s also because I had a chef for over two years in Los Angeles and now, it’s just me cooking for Clay and me,” she explained. “I’ve lost more weight here, and I am on Mounjaro for my diabetes, which has weight loss as one of its side effects.”

© Rosie O’Donnell/Instagram

In the video, she revealed how shopping for clothes in Dublin after losing weight was a surreal experience. “I’m one of those people who always had a weight issue, and now that I’m a size large instead of an XL or 2XL, I find it shocking,” she reflected.

© Monica Schipper

She also shared a lighthearted moment about her clothes fitting better, noting how surprising it was to wear pants without an elastic waistband for the first time in ages.

© Amanda Edwards

The photo showing her transformation gained attention from her fans and fellow celebrities. Kathy Griffin commented, “I LOVE THAT YOU’RE DOING STAND UP,” while a fan added, “Ireland looks good on you, Rosie!”